5 ethynyl 2 deoxyuridine sigma
2'Deoxyuridine is a naturally occurring nucleoside. It is similar in chemical structure to uridine, but without the 2'hydroxyl group. It is considered to be an antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis.Gold Biotechnology (U. S. Registration No 3, 257, 927) and Goldbio (U. S. Registration No 3, 257, 926) are registered trademarks of Gold Biotechnology, Inc. 5 ethynyl 2 deoxyuridine sigma
EdU (5ethynyl2 deoxyuridine) is a novel alternative for BrdU (5bromo2 deoxyuridine) assay to directly measure active DNA synthesis or Sphase synthesis of the cell cycle.
(EdU) is a thymidine analog that can be incorporated into replicating DNA for detection of cell proliferation. It has an alkyne handle that can ligate with azidecontaining fluorescent probes through a highly efficient click chemistry reaction. Derivatized 2Deoxyuridines used as labeling substrates include chloro2deoxyuridine (CldU), bromodeoxyuridine (BrdU) andor iododeoxyuridine (IdU). Other useful analogues of 2deoxyuridine include (DdU) and (HmdU). Packaging 1, 5 5 ethynyl 2 deoxyuridine sigma (EdU) is an extensively used nucleoside analog of thymidine used as a probe for DNA synthesis.
T SigmaAldrich (EdU) Aldrich CPR. CAS Number. Empirical Formula (Hill Notation) C 11 H 12 N 2 O 5. Molecular Weight 252. 22. MDL number MFCD. PubChem Substance ID 5 ethynyl 2 deoxyuridine sigma (EdU) and (EdC) are mainly used as markers of cellular replicational activity. Although EdU is employed as a replicational marker more frequently than EdC, its cytotoxicity is commonly much higher than the toxicity of EdC. EdU can be used as a replacement for BrdU and directly measures de novo DNA synthesis or Sphase synthesis of the cell cycle using click chemistry. Click chemistry is a method of covalently coupling an azide with an alkyne. Infoboxreferences (EdU) is a thymidine analogue which is incorporated into the DNA of dividing cells. EdU is used to assay DNA synthesis in cell culture and to detect cells which have undergone DNA synthesis in embryonic, neonatal and adult animals. Use of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed andor used, totally or in part, for noncommercial purposes provided that ECHA isRating: 4.34 / Views: 516